Careers

JOIN US

We are a collaborative and interdisciplinary team. If you are passionate about making a tangible difference and thrive in a dynamic environment, we invite you to apply to join our pioneering organization.
Open positions
Spyre Therapeutics executives celebrate their listing at the NASDAQ podium, with the company logo in the background.
Two clinicians educating an audience on the differences between ulcerative colitis and Crohn’s disease.
A diverse group of professionals gathered around a laptop at a wooden conference table, viewing content together. The team members are dressed in business casual.

Our values drive our culture

By holding ourselves to the highest standard of performance, together we challenge what’s possible and embrace diverse perspectives while maintaining a strong culture where courage and resilience are celebrated.

Breakthrough Discoveries

We target impactful improvements in therapeutic efficacy and convenience to meaningfully improve the lives of patients.

Uncompromising Innovation

We work at the highest level of scientific and clinical rigor, designing studies to answer critical questions with urgency.

Courageous Dissent

We bring strong, data-driven opinions and encourage diversity of thought to advance the best ideas.

Ownership Mindset

We hold ourselves to the highest standard of performance, quality, and integrity as we work through challenges and ambiguity.

A group of employees posing at the Tailgate party.

Inclusion,
belonging, and culture

Our team members foster a culture of empowering each other to bring our true selves to Spyre to reach new heights in the treatment of our patients. We do this by leveraging the power of diverse perspectives through mutual respect, equitable treatment and upholding an inclusive environment.

A group of employees holding skateboards from their Skate Like a Girl event.

Our benefit offerings

Spyre offers an opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly. We are committed to growing you professionally and providing access to resources to further your development.

Competitive compensation inclusive of base salary, performance bonus, equity grant opportunities, and retirement benefits

Coverage inclusive of medical, dental, vision, health and wellness reimbursements

Flexible PTO and two, one-week company-wide shutdowns each year

100% remote with frequent all team, in-person meetings to build relationships and problem solve

Open
Positions

We recognize that great talent isn’t confined to a specific geography. We are primarily remote, meaning we hire from anywhere in the United States. If you’re looking to make a big impact and work with a great group of people, we encourage you to apply today!

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Associate Director, Biostatistics

Remote
All open positions

Applying to Spyre Therapeutics

Please be aware that Spyre Therapeutics will never initiate contact with applicants via text message or through messaging apps, freelance sites, or social media platforms (Facebook, Telegram, Instagram, Skype, WhatsApp, etc.). Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.