Engineering for new heights in the treatment of IBD and beyond

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Our Approach

Spyre is developing next-generation antibodies that are engineered for prolonged activity in the body and formulated for delivery as monotherapies or combination therapies. Our innovative approach enables the exploration of treatment options with the potential to deliver uncompromising efficacy and convenience.

Learn about our approach

Our pipeline

Our pipeline of novel antibodies target validated mechanisms with the potential to treat several gastrointestinal and rheumatological conditions.

Program
Target
Phase 1
Phase 2
Phase 3
SPY001
α4β7
SPY002
TL1A
SPY003
IL-23
SPY120
α4β7 + TL1A
SPY130
α4β7 + IL-23
Spyre therapeutics pipeline
View our Pipeline

Our commitment to patients

We are committed to transforming the lives of patients and caregivers through our mission to develop improved treatment options for IBD and other immune-mediated diseases.

Our commitment
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Join Us

We are a collaborative and interdisciplinary team. If you are passionate about making a tangible difference and thrive in a dynamic environment, we invite you to apply to join our pioneering organization.

Explore Careers
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ABOUT US

Our team has deep experience developing and commercializing treatments across a broad
range of diseases, and is committed to improving the lives of patients.

Meet Our Team
Scott Burrows
Jonathan Campbell
Irving Cassidy
Brian Connolly
Melissa Cooper
Cristina Damatarca
Paul Fehlner
Joshua Friedman
Janet Gunzner-Toste
MiRa Huyghe
Dimitrios Kandylas
Heidy King-Jones
Justin LaFountaine
Eric McIntyre
Scott Burrows
Jonathan Campbell
Irving Cassidy
Brian Connolly
Melissa Cooper
Cristina Damatarca
Paul Fehlner
Joshua Friedman
Janet Gunzner-Toste
MiRa Huyghe
Dimitrios Kandylas
Heidy King-Jones
Justin LaFountaine
Eric McIntyre
James Myers
Deanna Nguyen
Ivan Noches
Mark Rose
Sheldon Sloan
Andrew Spencer
Cameron Turtle
Matthew Zinder
Jeffrey Albers
Peter Harwin
Michael Henderson
Tomas Kiselak
Mark McKenna
Sandra Milligan
James Myers
Deanna Nguyen
Ivan Noches
Mark Rose
Sheldon Sloan
Andrew Spencer
Cameron Turtle
Matthew Zinder
Jeffrey Albers
Peter Harwin
Michael Henderson
Tomas Kiselak
Mark McKenna
Sandra Milligan